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EC number: 252-552-9
CAS number: 35415-27-1
RESULTS OF PILOT STUDY: no irritation at concentrations
of 100% test substance
RESULTS OF TEST
- Sensitization reaction: 0/20
- Clinical signs: Local reactions after intradermal
application (test and control animals after 1 and 24 hours): All FCA
treated injections sites showed severe erythema, edema and necrosis. The
animals treated with 10% test substance in maize germ oil showed well
defined erythema and edema.
Local reactions after patch test (48 hours): 1 hour after
patch removal, test and control animals: whole application area showed
erythema and edema, as well as inflamed or bloody lesions, restlessness
of the animals and scratching in the application area.
24 hours after patch removal: Some animals showed
erythema and eschar formation in the whole application area.
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl
triesters was tested for dermal sensitisation in guinea pigs by the
Magnusson and Kligman maximisation test according to OECD guideline 406
(12 May 1981).
The sensitising potential of 1,2,4-Benzenetricarboxylic
acid, mixed decyl and octyl triesters was determined using a test group
of 20 and a control group of 10 animals. All reactions, especially the
formation of erythema and oedema, were assessed 48 and 72 hours after
the challenge treatment. The maximum concentration which caused no
dermal irritation in a prelinminary test was found to be 100% test
substance (as supplied).
The following concentrations of test substance were used
for the induction treatments: the test substance was employed in a 10%
mixture with maize germ oil for the intracutaneous injection, while the
100% test substance (as supplied) was used for the dermal treatment.
The preliminary test showed that the undiluted test
substance caused no dermal irritation. In order to induce slight to
moderate dermal inflammation, 24 hours before the dermal induction
treatment the skin in the injection area was pretreated with sodium
dodecyl sulphate (10% in vaseline).
All FCA treated injections sites (diluted 1 +1 with maize
germ oil), assessed 1 and 24 hours after intradermal induction
treatment, showed severe erythema, edema and necrosis. The control
animals had comparable signs of irritation at the injection sites.
The reactions to the dermal induction treatment for 48
hours were described as follows: 1 hour after patch removal, test and
control animals showed erythema and edema in the whole application area,
as well as inflamed or bloody lesions, the animals were restless and
showed scratching in the application area. 24 hours after patch removal
some animals showed erythema and eschar formation in the whole
The first challenge treatment was carried out with the
undiluted test substance (100%). No signs of dermal irritation were
found on the test animals or the control animals 48 and 72 hours after
the challenge treatment. No second challenge was carried out.
On the basis of these results, 1,2,4-Benzenetricarboxylic
acid, mixed decyl and octyl triesters was assessed as having no
sensitising effect on the skin of guinea pigs.
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