Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 27 July to 16 October 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted in GLP compliance and in accordance with several internationally established guidelines (OECD, EEC, EPA, see below).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
yes
Remarks:
Acetonitril/water was used as mobile phase instead of methanole/water as given in the guidelines
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): TH 1165 I
- Chemical Name: (4-Methoxyphenyl)-aceton
- Physical state: yellow liquid
- Analytical purity: 99.01 %
- Purity test date: 6. march 2000
- Lot/batch No.: 14
- Stability: Can be requested from the sponsor
- Storage condition of test material: at room temperature

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.9
Temp.:
25 °C
pH:
7
Remarks on result:
other: standard pH value assumed

Any other information on results incl. tables

Capacity Factor k' and log Pow of the Test Item

 Compound  Replicates  Retention Time1 [min]  Capacity Factor2  log k'  log Pow3
 TH1165 I  3  4.9  1.6  0.20  1.9
 TH1165 I  3  4.9  1.6  0.20  1.9
 TH1165 I  3  4.9  1.6  0.20  1.9
 mean value    4.9  1.6  0.20  1.9

1 mean value of three measurements, values represent rounded calculated from the exact raw data

2 calculated according equation (1)

3 calculated from regression data

Applicant's summary and conclusion

Conclusions:
The log Pow of the test material was calculated to be 1.9 at 25°C .