Registration Dossier
Registration Dossier
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EC number: 204-587-6 | CAS number: 122-97-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-09-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP and OECD Guideline conform study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 7 799 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- The concentration measured did not differ for more than 15 % and temperatures were kept constant within ± 0.5 °C. Thus, all validity criteria were fulfilled.
- Conclusions:
- The test substance has a water solubility of 7799 mg/L.
- Executive summary:
The water solubility of the test substance was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 440/2008, Method A.6. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C for 72, 48 and 24 h. The analytical method (HPLC-DAD, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility was determined to be 7799 mg/L at 20 °C at pH 7.
Reference
Water solubility results at 20 °C
Preincubation time |
Conc. Test item (mean of 2 replicates) [mg/L) |
24 h |
7790 |
48 h |
7795 |
72 h |
7813 |
Mean (24-48 h) |
7799 |
Description of key information
The water solubility of the test substance was determined to be 7799 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 7 799 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test substance was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 440/2008, Method A.6. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C for 72, 48 and 24 h. The analytical method (HPLC-DAD, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility was determined to be 7799 mg/L at 20 °C at pH 7.
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