Registration Dossier

Administrative data

Endpoint:
distribution modelling
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Value is predicted from model. Thus, it provides an approximation compared to experimental measure.

Data source

Reference
Reference Type:
other: unpublished calculation
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Model:
calculation according to Mackay, Level III
Calculation programme:
EPI Suite v4.11
Release year:
2 013
Media:
other: air- water- soil- sediment

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
Calculation is based on the structure and / or properties of quinidine

Results and discussion

Percent distribution in media

Air (%):
0
Water (%):
10.1
Soil (%):
83
Sediment (%):
6.85

Any other information on results incl. tables

   air  water  soil  sediment

mass amount (%)

0.00000133  10.1  83  6.85
half-life (hr)  1.5 900  1.8E+003  8.1E+003
emissions (kg/hr)  1000  1000  1000  0
fugacity (atm)   2.64E-019  7.8E-021  2.58E-021  9.55E-021

reaction (kg/hr)

 0.0365   462  1.9E+003 34.8

advection (kg/hr)

0.000788 600  0  8.13

reaction (%)

 0.00122  15.4  63.2  1.16

advection (%)

 0.0000263  20  0  0.271

persistence time: 1.98E+003 hr

reaction time: 2.48E+003 hr

advection time: 9.75E+003 hr

percent reacted: 79.7

percent advected: 20.3

half-lives (hr), (based upon Biowin and Aopwin):

air: 1.498

water: 900

soil: 1800

sediment: 8100

biowin estimate: 2.329 (weeks-months)

advection time:

air: 100

water: 1000

sediment: 5E+004

Applicant's summary and conclusion

Conclusions:
According to the calculated distribution quinidine mainly retains to soil.
Executive summary:

According to the fugacity model, Level III, the distribution of quinidine to air - water - soil - sediment is 0.00000133 - 10.1 - 83 - 6.85 %. These results show, that the majority retains in soil, while there are lower amounts available in the air, water and sediment.