Registration Dossier

Administrative data

Endpoint:
two-generation reproductive toxicity
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Toxicity of ethylene oxide determined on experimental animals.
Author:
HOLLINGSWORTH, R.L., ROWE, V.K., OYEN, F., MCCOLLISTER, D.D., & SPENCER, H.C.
Year:
1956
Bibliographic source:
Arch. ind. Health, 13: 217-227.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
guinea pig

Administration / exposure

Route of administration:
inhalation

Results and discussion

Results: F1 generation

General toxicity (F1)

Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
decrease

Effect levels (F1)

Dose descriptor:
conc. level:
Generation:
F1
Effect level:
370 mg/m³ air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: see 'Remark'

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion