Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-849-9 | CAS number: 75-21-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Human skin reactions to ethylene oxide
- Author:
- SHUPACK, J.L., ANDERSEN, S.R., & ROMANO, S.J.
- Year:
- 1 981
- Bibliographic source:
- J. Lab. clin. Med., 98: 723-729
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- patch test
Test material
- Reference substance name:
- Ethylene oxide
- EC Number:
- 200-849-9
- EC Name:
- Ethylene oxide
- Cas Number:
- 75-21-8
- Molecular formula:
- C2H4O
- IUPAC Name:
- oxirane
Constituent 1
In vivo test system
Test animals
- Species:
- human
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Vehicle:
- other: polyvinyl chloride
- Concentration / amount:
- 100 mg ethylene oxide/kg
Challengeopen allclose all
- Vehicle:
- other: polyvinyl chloride
- Concentration / amount:
- 100 mg ethylene oxide/kg
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 100mg/kg
- No. with + reactions:
- 1
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 100mg/kg. No with. + reactions: 1.0. Total no. in groups: 12.0.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
