Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Increased dominant-lethal effects due to prolonged exposure of mice to inhaled ethylene oxide.
Author:
GENEROSO, W.M., CUMMING, R.B., BANDY, J.A., & CAIN, K.T.
Year:
1983
Bibliographic source:
Mutat. Res., 119: 377-379

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Type of assay:
rodent dominant lethal assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse

Administration / exposure

Route of administration:
inhalation

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
positive
Toxicity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): positive