Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 807-085-0 | CAS number: 1004297-30-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Trimethylcyclohexylammonium sulfate , aqueous solution 50 wt.%
- IUPAC Name:
- Trimethylcyclohexylammonium sulfate , aqueous solution 50 wt.%
- Reference substance name:
- bis(N,N,N-trimethylcyclohexanaminium) sulfate
- EC Number:
- 807-085-0
- Cas Number:
- 1004297-30-6
- Molecular formula:
- 2 C9 H20 N .O 4S
- IUPAC Name:
- bis(N,N,N-trimethylcyclohexanaminium) sulfate
- Details on test material:
- - Name of test material (as cited in study report): Trimethylcyclohexylammonium sulfate , aqueous solution 50 wt.%
- Physical state: Liquid / colorless, clear
- Analytical purity: 51.8 g/100 g,
- Lot/batch No.: DENECKE00120
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Germany
- Age at study initiation: Young adult animals (female animals approx. 10 weeks)
- Weight at study initiation: Animals of comparable weight (± 20% of the mean weight)
- Housing: Single housing, Makrolon cage, type III
- Diet (e.g. ad libitum): VRF1(P); SDS Special Diets Services, 67122 Altrip, Germany
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: at least 5 days before the beginning of the experimental phase
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 30 – 70%
- Air changes (per hr): approx. 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
For the high dose, the liquid test item was administered undiluted. For the lower dose, an administration volume of 2 mL/kg bw of suitable test item preparations was used to facilitate application. 600 and 300 mg/kg bw: The test item was prepared in deionized water and homogenized for each dose group shortly before and during administration by stirring with a magnetic stirrer. - Doses:
- 300, 600 and 2000 mg/kg bw (150, 300 and 1000 mg/kg bw acutal dose; to ensure the actual dose, the content of active ingredient (approx. 50%) was taken into account.)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights shortly before administration (day 0), weekly thereafter and on the last day of observation.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology: yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 600 - < 2 000 mg/kg bw
- Remarks on result:
- other: acutal dose of greater than 300 mg/kg bw and less than 1000 mg/kg bw.
- Mortality:
- All animals of the 2000 mg/kg bw test group were found dead within 2 or 3 hours after administration. No mortality occurred in both 600 and 300 mg/kg bw test groups.
- Clinical signs:
- other: In all animals of the 2000 mg/kg bw test group impaired general state was observed at hour 0 and persisted in two of these animals until hour 1 after administration. Thereafter, poor general state was noted in two out of three animals at hour 1 or 2. In t
- Gross pathology:
- The following macroscopic pathologic findings were observed in the three animals that were found dead in the 2000 mg/kg bw test group: Red discoloration of the glandular stomach and small intestine, swollen glandular stomach and swollen small intestine
There were no macroscopic pathological findings in the animals sacrificed at the end of the observation period (600 mg/kg bw: 6 females, 300 mg/kg bw: 6 females).
Any other information on results incl. tables
Under the conditions of this study the median lethal dose of Trimethylcyclohexylammonium sulfate , aqueous solution 50 wt.% after oral administration was found to be greater than 600 mg/kg bw and less than 2000 mg/kg bw in rats (actual dose of greater than 300 mg/kg bw and less than 1000 mg/kg bw).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.