Manganese, 3-hydroxy-4-[(1-sulfo-2-naphthalenyl)azo]-2-naphthalenecarboxylic acid complex

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1984-08-08 - 1984-12-18

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: non GLP, scientifically acceptable study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Objective of study:

excretion

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Manganese, 3-hydroxy-4-[(1-sulfo-2-naphthalenyl)azo]-2-naphthalenecarboxylic acid complex

EC Number:

252-525-1

EC Name:

Manganese, 3-hydroxy-4-[(1-sulfo-2-naphthalenyl)azo]-2-naphthalenecarboxylic acid complex

Cas Number:

35355-77-2

Molecular formula:

C21H12MnN2O6S

IUPAC Name:

manganese(2+) hydrogen 3-oxido-4-[(E)-(1-sulfonatonaphthalen-2-yl)diazenyl]naphthalene-2-carboxylate

Radiolabelling:

no

Test animals

Species:

rat

Strain:

other: Til:RAI f SPE

Sex:

male

Details on test animals or test system and environmental conditions:

ENVIRONMENTAL CONDITIONS
- Temperature: 21 +/- 1 °C
- Humidity: 65 % +/- 5 %

Administration / exposure

Route of administration:

oral: gavage

Duration and frequency of treatment / exposure:

single treatment

Doses / concentrations

Remarks:

Doses / Concentrations:
1 m³ of the formulation per animal corresponding to 33.17 mg/animal of the test substance

No. of animals per sex per dose / concentration:

4 rats divided into two groups

Control animals:

yes

Details on study design:

rats received a single oral dose of 33.7 mg/animal of the test item and 10.0 mg/animal of β-naphthylamine. The residues of β-naphthylamine in urine of rats were measured after 24 hours and 48 hours.

Details on dosing and sampling:

PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: 24h, 72h

Statistics:

none

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:

No residues of β-naphthylamine (<0.06 mg/dm3) were found in urine of rats within 48 hours after a single oral treatment with the test substance at a dose of 33.17 mg/animal. After a single oral treatment with β-naphthylamine at a dose of 10 mg/animal, residues of β-naphthylamine were found to range between 3.5 and 5.1 mg/dm3 in the 0-24 hours samples and to decrease to 0.14-0.24 mg/dm3 in the 24-48 hours samples.

Any other information on results incl. tables

Residues of  β-naphthylamine in urine of rats after treatment with β-naphthylamine and with the test substance

Test substance	Animal No.	Animal weight g	Application dosis mg/animal	β-naphtylamine mg/dm3
				0-24h	24-48h
β-naphthylamine	84185 plus      84186	201.4 199.2	10.0 10.0	3.5	0.14
	84187 plus      84188	210.4 201.2	10.0 10.0	5.1	0.24
Test substance	84177 plus      84178	205.7 199.4	33.17 33.17	<0.06	<0.06
	84179 plus      84180	198.4 203.8	33.17 33.17	<0.06	<0.06
Control	84189 plus      84190	197.3 208.4	- -	<0.06	<0.06
	84191	194.4	-	<0.06	<0.06