Registration Dossier
Registration Dossier
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EC number: 252-525-1 | CAS number: 35355-77-2 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 15880:2.
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The test item is with high probability not acutely harmful to aquatic invertebrates. No toxic effects occur within the range of solubility.
Key value for chemical safety assessment
Additional information
The toxicity of the read-across substance CAS 6417-83-0 to aquatic invertebrates was examined in a non-GLP study according to OECD guideline 202 (BASF 2000). In this study, Daphnia magna (4 replicates of 5 animals per concentration) were exposed to nominal concentrations of 12.5, 25, 50, 100 mg/L and a blank control for 48 hours. The test solutions were saturated for 20 h and undissolved test material was removed by centrifugation. The loading rate of the eluate was 100 mg/L and the test concentrations were produced by diluting the eluate. No analytical verification of nominal test concentrations was performed. At the start of the test and after 24 and 48 hours each test vessel was visually checked for immobilised daphnids. After 48 hours, at the highest concentration tested, a single test organism was found to be immobile. No additional adverse effects or abnormal behaviour are reported in any of the test treatments. Based on these findings, the 48-h EC50 value is determined at >100 mg/L (nominal).
Additionally, results of a toxicity study to Daphnia magna according OECD 203 and GLP with the read-across substance (CAS 7023-61-2; RCC Ltd. 2007) are available. Due to the low solubility of the test substance a water accommodated fraction has been used. No effects have been observed after 48 h with the loading rate of 100 mg/L. Therefore, the EC50 after 48 h was determined to be > 100 mg/L (nominal) and the NOEC was determined to be >= 100 mg/L.
Hence, the test item is with high probability not acutely harmful to aquatic invertebrates. No toxic effects occur within the range of solubility.
The read-across justification is attached in chapter 13.
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