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EC number: 204-112-2 | CAS number: 115-86-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short report. Main features of study design given. Also assessed by OECD.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Similar to limit test but higher dose is used.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18H15O4P
- IUPAC Name:
- triphenyl phosphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wistar derived
- Weight at study initiation: 200-300 grams
- Fasting period before study: 24hours
- Housing: mesh bottom cages
- Diet (e.g. ad libitum): Available after dosage
Water (e.g. ad libitum): Available after dosage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% in aqueous solution - Doses:
- Single dose of 20,000 mg/kg of the test material.
- No. of animals per sex per dose:
- 5 males, 5 females (10).
- Control animals:
- no
- Details on study design:
- Ten young adult albino rats weighing between 200-300 grams equally distributed into five males and five females were housed in mesh-bottom cages and fasted 24 hours prior to administrating a single dose of 20,000 mg/kg of the test material. Food and water were available ad libitum after dosage. The animals were observed daily for 14 days following adminsitration of the test material and deaths were recorded.
Results and discussion
- Preliminary study:
- No mortality was observed at the dosage level of 20,000 mg/kg of body weight. Gross examination at autopsy revealed sporadic visceral hemorrhage.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: No information on clinical signs.
- Gross pathology:
- Gross examination at autopsy revleaed sporadic visceral hemorrhage.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- The approximate acute oral LD50 for TPP in rats is >20,000 mg/kg of body weight.
- Executive summary:
In an acute oral toxicity test in rats, ten young adult albino rats weighing between 200-300 grams equally distributed into five males and five females were housed in mesh-bottom cages and fasted 24 hours prior to administrating a single dose of 20,000 mg/kg of the test material TPP (in 25% aqueous solution). The dose was administered via intragastric intubation. Food and water were available ad libitum after dosage. The animals were observed daily for 14 days following administration of the test material and deaths were recorded. No mortality was observed at the administered dose. Gross examination at autopsy revealed sporadic visceral hemorrhage. The approximate acute oral LD50 obtained for the test material TPP is >20,000 mg/kg of body weight.
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