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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Mixture cotaining only 35% TPP tested. Also assessed by OECD.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1987

Materials and methods

Type of study / information:
Type: adsorption
Principles of method if other than guideline:
Metabolism, in vivo: rat, single i. p. injection of 300 mg of a commercial plasticizer containing 35 % TPP and several cresylphosphate isomeres: determination of TPP in the liver and blood after 4 h and 24 h determination of induction of microsomal cytochrome P-450 in the liver, pseudocholine esterase in plasma, histopathology of caudal nerves
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Triphenyl phosphate
EC Number:
204-112-2
EC Name:
Triphenyl phosphate
Cas Number:
115-86-6
Molecular formula:
C18H15O4P
IUPAC Name:
triphenyl phosphate

Results and discussion

Any other information on results incl. tables

Metabolism, in vivo: 
TPP in the liver after 4 h 36.6±23.3 µg/g, after 24 h 1.8±1.9 µg/g;
in blood: TPP after 4h: 0.7+-0.3 µg/g, 24 h not detectable 
induction of microsomal cytochrome P-450 in the liver,
decrease of pseudocholine esterase in plasma, 
swollen myelin sheaths in caudal nerves 2 weeks after injection of 300  mg/kg.

Applicant's summary and conclusion

Executive summary:
Metabolism, in vivo: rat, single i. p. injection of 300 mg
of a commercial plasticizer containing 35 % TPP and several cresylphosphate isomeres:
determination of TPP in the liver and blood after 4 h and 24 h
determination of induction of microsomal cytochrome P-450 in the liver, pseudocholine esterase in plasma,
histopathology of caudal nerves. 
Metabolism, in vivo: 
TPP in the liver after 4 h 36.6±23.3 µg/g, after 24 h 1.8±1.9 µg/g;
in blood: TPP after 4h: 0.7+-0.3 µg/g, 24 h not detectable 
induction of microsomal cytochrome P-450 in the liver,
decrease of pseudocholine esterase in plasma, 
swollen myelin sheaths in caudal nerves 2 weeks after injection of 300  mg/kg.