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EC number: 202-200-5 | CAS number: 92-88-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23-07-2012 to 03-08-2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Proprietary GLP study report.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Biphenyl-4,4’-diol / CAS 92-88-6
- Key result
- Water solubility:
- 33.7 mg/L
- Temp.:
- 20 °C
- pH:
- 6.5
- Conclusions:
- The solubility of the test item was determined to be 33.7 mg/L (pH 6.5) at 20 +/- 0.5 °C. The substance is considered pratically insoluble (solubility < 0.1 g/L)
- Executive summary:
The water solubility of 4,4-Biphenol was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 440/2008, Method A.6 from 2012-07-23 to 2012-08-03 at Dr.U.Noack-Laboratorien, 31157 Sarstedt, Germany.
The decision for employing the flask method was based on preliminary testing (non GLP), where a solubility of approximately 10 mg/L was observed.
The solubility of the test item 4,4-Biphenol was determined using the flask method at 20 ± 0.5 °C with preincubation at 30 ± 0.5 °C.
The analytical method (HPLC-DAD, external standard) for the determination of the test item 4,4-Biphenol was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.
The water solubility of 4,4-Biphenol was determined to be 33.7 mg/L (20 °C, pH 6.5).
Reference
Water Solubility Results at 20 °C for 4,4-Biphenol
Sample |
Replicate No. |
4,4-Biphenol |
|
Concentration2) |
Mean |
||
24 h |
1 |
33.8 |
33.7 |
2 |
33.7 |
||
48 h |
1 |
32.5 |
33.4 |
2 |
34.4 |
||
72 h |
1 |
35.2 |
34.0 |
2 |
32.9 |
||
Mean (24 - 72 h) |
|
|
33.7 |
Deviation [%]1) |
1.8 |
||
1) Calculated according to Formula, Deviation (%) = 100 x (max value - min value) / min value.
2) Mean value of two injections, dilution factor of 2 taken into account
The analytical method (HPLC-DAD, external standard) for the determination of the test item 4,4-Biphenol was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.
Description of key information
The solubility of the test item was determined to be 33.7 mg/L (pH 6.5) at 20 +/- 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 33.7 mg/L
- at the temperature of:
- 20 °C
Additional information
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