Registration Dossier
Registration Dossier
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EC number: 203-560-6 | CAS number: 108-20-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1938
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies, information in published paper is insufficient
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 938
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no justification for species used
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP requirements
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- other: liquid
- Details on test material:
- - Physical state: Liquid
- Analytical purity: Commercial grade with 3% isopropyl alcohol
Constituent 1
Test animals
- Species:
- monkey
- Strain:
- other: macacus rhesus
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- >= 20 - <= 180 min
- Concentrations:
- 0.1, 0.3, 1, 3, or 6 %
- No. of animals per sex per dose:
- 1
- Control animals:
- other: yes; only mentioned in results section with no details provided
Results and discussion
Effect levels
- Dose descriptor:
- other: no LD50 reported
- Remarks on result:
- other: Authors did not report an LD50
Any other information on results incl. tables
0.3 % (~3000 ppm) for 2 hours: No visible indication of anesthetic action.
1 and 3.0 % (~30000 ppm) for 1 hour: Not lethal; signs of anesthesia
6.0% (~60000 ppm): Death as the result of respiratory failure within 1 hour
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)
- Conclusions:
- Assuming a temperature of 20 ºC and an atmospheric pressure of 1 atm, 30000 ppm corresponds to 64 mg/L, which was the non-lethal but anaestetic dose in this study.
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