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Diss Factsheets
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EC number: 206-992-3 | CAS number: 420-04-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Medical data/ clinical observations
- Adequacy of study:
- supporting study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- For details on principles of method see below.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyanamide
- EC Number:
- 206-992-3
- EC Name:
- Cyanamide
- Cas Number:
- 420-04-2
- Molecular formula:
- CH2N2
- IUPAC Name:
- cyanamide
- Test material form:
- other: aqueous solution
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- A 29 year old man
- Ethical approval:
- not applicable
- Route of exposure:
- other:
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
- Details on exposure:
- It is reported that a 29 year old man became ill, while spraying kiwi trees with cyanamide. The applicator was wearing a Tyvek suit, rubber boots, rubber gloves and a half-face respirator. He started spraying in the morning. He quit for lunch and removed his protective ensemble without decontamination.
- Medical treatment:
- No data
Results and discussion
- Clinical signs:
- This worker experienced hypotension, vertigo, nausea, puffiness of the face and hypokalemia without exposure to alcohol while applying Hydrogen cyanamide. The hypotension was without tachycardia and lasted four days after the exposure.
Any other information on results incl. tables
While the employee denied consuming any alcoholic beverages or having any illness prior to working the day of the exposure, the employer developed the information that the employee attended a party the night before, was complaining of a cold when he went to work that day and had a canister fall off his respirator the morning of the illness. Typically, illness with cyanamide has been associated with Antabuse reaction when used with alcohol.
Applicant's summary and conclusion
- Conclusions:
- Typically, illness with cyanamide has been associated with Antabuse reaction when used with alcohol.
- Executive summary:
It is reported that a 29 year old man became ill, while spraying kiwi trees with cyanamide. The applicator was wearing a Tyvek suit, rubber boots, rubber gloves and a half-face respirator. He started spraying in the morning. He quit for lunch and removed his protective ensemble without decontamination. After lunch he started to stand up and became so dizzy that he collapsed, vomited twice and was taken to the hospital. This worker experienced hypotension, vertigo, nausea, puffiness of the face and hypokalemia without exposure to alcohol while applying hydrogen cyanamide. He was wearing a full protective ensemble and there was no patient history or objective signs of alcohol use. The hypotension was without tachycardia and lasted four days after the exposure. The employee did not decontaminate before removing his protective ensemble for lunch but he was slightly ill in the morning. His illness accelerated after lunch. While the employee denied consuming any alcoholic beverages or having any illness prior to working the day of the exposure, the employer developed the information that the employee attended a party the night before, was complaining of a cold when he went to work that day and had a canister fall off his respirator the morning of the illness. Typically, illness with cyanamide has been associated with Antabuse reaction when used with alcohol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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