Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-992-3 | CAS number: 420-04-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: Medicak data/ clincal observations
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- For details on principles of method see below.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyanamide
- EC Number:
- 206-992-3
- EC Name:
- Cyanamide
- Cas Number:
- 420-04-2
- Molecular formula:
- CH2N2
- IUPAC Name:
- cyanamide
- Details on test material:
- - Name of the test substance: Cyanamide (Colme: hydrogen cyanamide)
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Subjects:
- Workers in a psychiatric ward assistanting in handling numerous medicines (mostly in the form of capsules and pills and sometimes as solutions like Colme)
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- Specific tests were performed with the medicines he normally handled; he gave a +++ positive reaction to Colme at 10 and 50 %. The reactions were still visible after 30 days as a bluish-black coloration. Thirty controls were negative. Colme contains 6 g per 100 mL of cyanamide in a stabilising vehicle of sorbic acid, sedium acetate and distilled water. Patch tests with the substances showed positive reactions only to cyanamide at 0.1, 0.5, 1 and 5 % in water at 48 and 96 h. All control tests were negative. The worker henceforth avoided all contact with Colme and his dermatitis resolved completely.
Any other information on results incl. tables
No remarks
Applicant's summary and conclusion
- Conclusions:
- An allergic contact dermatitis to cyanamide (carbodiimide)
- Executive summary:
A 32-year old man had been working for a year and a half in a psychiatric ward as an assistant handling numerous medicines, mostly in the form of capsules and pills and sometimes as solutions. Four months ago, the pulps of his thumb, index and middle fingers on the right hand, showed an erythemato-squamous dermatitis which was very itchy and later developed fissuring. He did not respond to topical applications and antihistamines. He noted, however, that the dermatitis sometimes improved spontaneously when he was away from work. During a normal working day he was in direct contact with about 40 medicines, such as tranquillisers, neuroleptics, vitamins, antialcoholic drugs, etc. Specific tests were performed with the medicines he normally handled; he gave a +++ positive reaction to Colme at 10 and 50 %. The reactions were still visible after 30 days as a bluish-black coloration. Thirty controls were negative. Colme contains 6 g per 100 mL of cyanamide in a stabilising vehicle of sorbic acid, sedium acetate and distilled water. Patch tests with the substances showed positive reactions only to cyanamide at 0.1, 0.5, 1 and 5 % in water at 48 and 96 h. All control tests were negative. The patient henceforth avoided all contact with Colme and his dermatitis resolved completely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.