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EC number: 269-052-1
CAS number: 68186-90-3
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77310.
CONTENT OF Ni AND Sb in:
LIVER: Mean Sb
concentration (quantification limit 0.2 ng/g) in unexposed animals was
1.1 ng/g; directly post-exposure and on day 3-post-exposure the
concentration was about 4-fold higher in exposed animals, and during
later observation the concentration was similar to unexposed animals
(1.3 ng/g on day 10). Mean Ni-concentration was in the same range in
exposed and unexposed animals (however, below the quantification limit
of 10 ng/g; outliers not considered).
KIDNEYS: Mean Sb
concentration in unexposed animals was below the detection limit (1
ng/g), in exposed animals it was above the detection limit but below the
quantification limit (3 ng/g), only the day 3 post exposure group
reached a value of 5.6 ng/g (2-3-fold increase compared with other
observation days). Mean Ni concentration was below the detection limit
(1 ng/g) in unexposed animals and above detection limit but below
quantification limit (25 ng/g) in exposed animals, except on day 3
post-exposure 94 ng/g were determined (10-fold more than in other
exposure groups. Authors comment: presumably due to contamination of the
post-exposure the mean Ni and Sb concentration was 79 and 202 µg/lung ,
respectively (corresponding to 2 mg of pigment/lung). The concentration
declined during the post-exposure period, following first order
kinetics; the clearance half-life was 50 days.
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