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EC number: 269-052-1 | CAS number: 68186-90-3 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77310.
Toxicological information
Skin irritation / corrosion
Currently viewing:
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (non-GLP, occlusive dressing, no washing after 24 h of exposure)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- secondary source
- Title:
- C.I. Pigment Brown 24
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 15
Materials and methods
- Principles of method if other than guideline:
- Before OECD Guideline 404 was established in 1982, skin irritation was tested according to the acknowledged Draize test method.
An amount of 0.5 mL of test material was applied to a skin area of 2.5 x 2.5 cm under occlusive conditions for 24 hours. The application site was either intact or scarified. The application site on the intact skin was located dorsally whereas the area of scarified skin was located on the left side. Skin findings were assessed after 24 hours, 48 hours, 72 hours and after 8 days. The assessment of the findings was based on the Federal Reg. 38, No. 187, Para. 1500.41, page 27029 (1973). - GLP compliance:
- no
Test material
- Reference substance name:
- Chrome antimony titanium buff rutile
- EC Number:
- 269-052-1
- EC Name:
- Chrome antimony titanium buff rutile
- Cas Number:
- 68186-90-3
- Molecular formula:
- (Ti, Sb, Cr) O2
- IUPAC Name:
- manganese(4+) trititanium(4+) pentaantimony(3+) chromium(3+) nickel(2+) octadecaoxidandiide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach, Germany
- Mean weight at study initiation: 2.50 kg
- Diet: Sniff
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Amount / concentration applied:
- Concentration: 50 %
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 8 days
- Number of animals:
- 6 (2 males, 4 females)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 * 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing: no
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 24 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 72 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 24 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 72 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 24 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 72 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 24 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 72 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 24 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 72 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 24 hours not possible due to substance related staining.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 72 h
- Remarks on result:
- not determinable
- Remarks:
- Evaluation of erythema after 72 hours not possible due to substance related staining.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No oedema was observed 8 days after test item treatment.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No oedema was observed 8 days after test item treatment.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No oedema was observed 8 days after test item treatment.
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No oedema was observed 8 days after test item treatment.
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No oedema was observed 8 days after test item treatment.
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No oedema was observed 8 days after test item treatment.
Any other information on results incl. tables
Abraded skin:
Evaluation of erythema impossible after 24 and 72 h due to colouring of skin, no erythema after 8 days but scaling in 3/6 rabbits. Edema in 4/6 rabbits after 24 h, no edema after 72 h or 8 d.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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