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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP

Data source

Reference
Reference Type:
publication
Title:
Percutaneous absorption of aliphatic compounds.
Author:
Iwata Y, Moriya Y, Kobayashi T
Year:
1987
Bibliographic source:
Cosmet. Toiletries 102(2): 53-68.

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
liquid
Radiolabelling:
yes

Test animals

Species:
mouse
Strain:
other: HR/De
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Remarks:
also tested in three solvent vehicles: TEC, castor oil and squalane.
Duration of exposure:
24 hours
Doses:
Up to 100% concentration in three vehicles and undiluted
No. of animals per group:
3
Control animals:
no

Results and discussion

Percutaneous absorption
Dose:
100%
Parameter:
percentage
Absorption:
ca. 7 %
Remarks on result:
other: 24 hours

Any other information on results incl. tables

The percentage absorbance of dose 14C-decyl alcohol (decanol) = ca 8 %. At least 65% of the absorbed dose is excreted as carbon dioxide in the expired air.

When tested diluted in solvent vehicles, the degree of absorption was influenced by the concentration and the type of solvent that was used.

For n-decyl alcohol in squalane, the fraction of the dose that was absorbed varied between approximately 5% of the applied dose at 50% concentration to approximately 27% of the applied dose at 0.5% concentration.

For n-decyl alcohol in castor oil, approximately 5% of the applied dose was absorbed at all tested concentrations (<0.1% - 50%).

For n-decyl alcohol in TEC (triethyl citrate), approx 5 -7% of the applied dose was absorbed at concentations of 0.5 -50%.

Applicant's summary and conclusion

Conclusions:
Of a dose of undiluted 1-14C-decyl alcohol applied to the skin of nude mice for 24 hours, 8 % was absorbed.
Executive summary:

Of a dose of undiluted 1-14C-decyl alcohol applied to the skin of nude mice for 24 hours, 8% was absorbed.