Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data obtained from a secondary source
Principles of method if other than guideline:
Method: other: (measured)
Water solubility:
4 mg/L
Temp.:
25 °C
Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
Water solubility value of 4 mg/l was reported for the substance
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-09-24
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods (ASTM) without GLP.
Qualifier:
according to
Guideline:
other: ASTM E 1148
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Water solubility:
1 mg/L
Temp.:
23 °C
pH:
5.5
Remarks on result:
other: Standard Deviation for these Data : +/- 0.1 mg/L

Measurement

(triple determination)

Results: 1.1 mg/L / 1.0 mg/L / 1.0 mg/L

Mean Concentration in Water: 1.0 mg/L

Standard Deviation for These Data: ±0.1 mg/L

Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility was determined to be 1.0 mg/l at 23 °C.
Executive summary:

Dodecan-1 -ol was determined according ASTM E 1148. The water solubility was determined to be 1.0 mg/l at 23 °C.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This result was obtained from a secondary source which is peer-reviewed.
GLP compliance:
not specified
Type of method:
other: slow-stir procedure
Water solubility:
1.93 mg/L
Temp.:
20 °C
Remarks on result:
other: The pH of the solution is not stated, but since the substance is only a very weak acid (pKa ca. 16) it is anticipated to create a neutral solution.
Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
A water solubility value of 1.93 mg/L was reported in a collection of reliable data which has been subject to peer-review. The result is considered to be reliable.
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data obtained from a secondary source
Principles of method if other than guideline:
Method: other
GLP compliance:
not specified
Water solubility:
1.7 - 2.9 mg/L
Temp.:
16 °C
Remarks on result:
other: The pH of the solution is not stated, but since the substance is only a very weak acid (pKa > 16) it is anticipated to create a neutral solution.
Water solubility:
2.9 mg/L
Temp.:
34 °C
Remarks on result:
other: The pH of the solution is not stated, but since the substance is only a very weak acid (pKa > 16) it is anticipated to create a neutral solution.
Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
Water solubility of the substance was obtained from a secondary source

Description of key information

The water solubility of a commercial sample of dodecan-1-ol is 1 mg/L at 23°C and pH 5.5.

Key value for chemical safety assessment

Water solubility:
1 mg/L
at the temperature of:
23 °C

Additional information

The solubility of 1 mg/L at 23°C and pH 5.5 was determined for the substance with the use of a flask method in accordance with ASTM E 1148. The result is considered to be reliable.

It is supported by a value of 1.93 mg/L, taken from a reliable and definitive reference source for solubility data (Letinski, 2002) and consistent results from other reference sources.

 

The value taken from literature for pure alcohol is used in exposure modelling.

 

Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:

As chain length increases, water solubility decreases, because the free energy required for a molecule to dissolve becomes less favourable for larger molecules.