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EC number: 218-690-9
CAS number: 2216-51-5
Short description of key information on bioaccumulation potential result: L-, DL, and unspecified Menthol isomers were well absorbed via the oral (dermal 100 % assumtion) route of exposure. They were mainly excreted as glucuronic acid conjugates. In rats an extensive enterohepatic circulation leads in addition to various hydoxylated degradation products. Glucuronides and degradation products were mainly eliminated via urine, minor quantities via the faeces. Thus, both in animals and humans menthol seems to be metabolized in a similar way, being rapidly glucuronidated and excreted mainly via urine.
L-, DL, and unspecified Menthol isomers were well absorbed via the oral
rout and as a worst case assumption also by dermal route. They were
mainly excreted as glucuronic acid conjugates. Glucuronides and
degradation products were fast eliminated mainly via urine, minor
quantities via the faces. In one study reliable 1 study the total
excretion in rats was after 17 h was 56,5% of given dose correlating to
about 90% of the recoverd Menthol activity. Additional recovered
activity was found in ileum 3.5%, fat 2.1 %, liver 0.8%, Serum
0.31%,Kidney 0.2%, Brain < 0.1%, Testis < 0.1%. Administrated menthol in
soft gelatine capsuls to human probands was fast absorbed and excreted
(halflife of excetrion 2 -4h).
Menthol glycuronic acid appeared in the urine of rabbits in less than an
hour after gavage dosing menthol, and 90 per cent of the conjugated acid
was found to be excreted in 6 hours when 2 g of menthol were feed. Even
when larger doses were given over 90 per cent of the total amount
excreted appeared in the urine during the first 24 hours.
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