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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a very short abstract available

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
A dermal LD50 study was conducted on a group of 10 rabbits, and a single application of 5 g/kg was administered. The animals were observed for mortality and/or clinical signs for 14 day.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
L-menthol
EC Number:
218-690-9
EC Name:
L-menthol
Cas Number:
2216-51-5
Molecular formula:
C10H20O
IUPAC Name:
2-isopropyl-5-methylcyclohexanol
Details on test material:
no further details given

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no further details given

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no further details given
Duration of exposure:
no further details given
Doses:
a single application of 5 g/kg
No. of animals per sex per dose:
10 rabbits were exposed
Control animals:
not specified
Details on study design:
A dermal LD50 study was conducted on a group of 10 rabbits, and a single application of 5 g/kg was administered. The animals were observed for mortality and/or clinical signs for 14 day.
Statistics:
no further details given

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
not specified
Mortality:
no mortality observed
Clinical signs:
other: no adverse clinical cisgns reported
Gross pathology:
no further details given
Other findings:
no further details given

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 > 5000 mg/kg
L-Menthol appears to be non toxic under tested conditions.