Registration Dossier
Registration Dossier
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EC number: 201-178-4 | CAS number: 79-11-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1-29 March 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Instead of 5 rats/sex/group, 10 females/group were used.
- GLP compliance:
- no
- Remarks:
- did not exist at that time
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Details on test material:
- - Name of test material (as cited in study report): Monochloressigsaure VM 2308
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1%
MAXIMUM DOSE VOLUME APPLIED: max 16 ml/kg - Doses:
- 40 mg/kg
63 mg/kg
100 mg/kg
160 mg/kg - No. of animals per sex per dose:
- 10 females/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly weighing and no data on observation scheme
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic examination - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 90.4 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 73.6 - 112
- Mortality:
- 40 mg/kg 0/10
63 mg/kg 2/10
100 mg/kg 5/10
160 mg/kg 10/10 - Clinical signs:
- other: Animals which died during study: restless behaviour, uncoordinated movements, hunched posture, lethargy, lacrimation, piloerection, pulsing respiration. Surviving animals showed these symptoms at lower severity and recovered from all symptoms within 48 h
- Gross pathology:
- Surviving animals: no findings
Animals which died during the study showed red-brown and highly vascularised liver with patch pattern, red-pink lungs with foci. Spleen was black discolored at the stomach-side.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Oral LD50= 90.4 mg/kg
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