Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-178-4 | CAS number: 79-11-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monochloroacetic acid toxicity in the mouse associated with blood-brain barrier damage
- Author:
- Berardi
- Year:
- 1 986
- Bibliographic source:
- Dissertation, Rutgers The State U. of N.J. - New Brunswick and U.M.D.N.J., May1986 (Abstract: Ref.167)
- Reference Type:
- publication
- Title:
- EU RAR MCAA
- Author:
- EU RAR
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- monochloroacetic acid
- IUPAC Name:
- monochloroacetic acid
- Details on test material:
- not specified
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 1-14C-MCAA
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- Pre-treatment for 2 minutes with 400 mg/kg molten (65C) MCAA
3 minutes 0.6 mg/kg 1-14C-MCAA - Doses:
- Pre-treatment for 2 minutes with 400 mg/kg molten (65C) MCAA
3 minutes 0.6 mg/kg 1-14C-MCAA - No. of animals per group:
- not specified
- Control animals:
- no
- Details on study design:
- With or without pre-treatment of the skin with 400 mg/kg molten (65C) MCAA before treatment for 3 minutes with 0.6 mg/kg 1-14C-MCAA. Different temperature 25 compared to 65 degrees.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- no data
- Total recovery:
- no data
Applicant's summary and conclusion
- Conclusions:
- Significant increase in absorption after pre-treament of the skin with molten MCAA. No significant difference in radioacitivity in plasma, whole brain, skin and urine of mice comparing the 65 and 25 degree solution after 6 hours.
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