Registration Dossier
Registration Dossier
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EC number: 201-178-4 | CAS number: 79-11-8
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No detailed exposure assessment. Limited information available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Pediatric fatality associated with accidental oral administration of monochloroacetic acid (MCA)
- Author:
- Feldhaus K, Hudson D, Brent J et al.
- Year:
- 1 993
- Bibliographic source:
- Vet. Hum. Toxicol. 35, 344
- Reference Type:
- publication
- Title:
- Accidental fatal monochloroacetic acid poisoning
- Author:
- Rogers DR
- Year:
- 1 995
- Bibliographic source:
- Am. J. Forensic Med. Pathol. 16(2): 115-116
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Reference substance name:
- 80% MCA wart remover (Verzone)
- IUPAC Name:
- 80% MCA wart remover (Verzone)
- Details on test material:
- Not specified.
Constituent 1
Constituent 2
Method
- Type of population:
- general
- Subjects:
- one 5 year old girl
- Ethical approval:
- not applicable
- Route of exposure:
- oral
- Reason of exposure:
- accidental
- Exposure assessment:
- estimated
- Details on exposure:
- Accidental pediatric exposure to 5-6 cc (from a bottle resembling Triaminocol decongestant). A post-mortem serum MCA level of 100 microgram/L (determined by GC/MS) confirmed the ingestion.
- Examinations:
- Blood pressure, heart rate, respiratory rate, temperature, physical examination, blood analysis, autopsy
- Medical treatment:
- Resuscitation for 6 hours.
Results and discussion
- Clinical signs:
- Immediately after exposure: vomiting and collapse soon thereafter.
45 minutes after exposure: no distress, pale, slightly mottled skin. - Results of examinations:
- 1.5 hours post ingestion: refractory ventricular tachycardia, pulmonary oedema, and unmanagable metabolic acidosis.
8 hours after ingestion: death.
Autopsy: diffuse gastric erosions, marked gastric mucosal hyperaemia, fatty liver, and pulmonary and cerebral oedema. - Effectivity of medical treatment:
- Not effective; patient died 8 hours post ingestion.
- Outcome of incidence:
- Death
Applicant's summary and conclusion
- Conclusions:
- Death occurred within 8 hours after ingestion of 5-6 cc 80% MCA in a 5-year old girl.
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