Triethylamine

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vivo (non-LLNA)

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: summary of the study report is available

Data source

Reference

Reference 1

Reference Type:

other: USEPA TSCA 8(d) submission

Title:

Unnamed

Year:

1958

Report date:

1958

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

no data

GLP compliance:

not specified

Type of study:

intracutaneous test

Test material

Test material information

Constituent 1

Reference substance name:

Triethylamine

EC Number:

204-469-4

EC Name:

Triethylamine

Cas Number:

121-44-8

Molecular formula:

C6H15N

IUPAC Name:

triethylamine

Details on test material:

Triethylamine, no further data

In vivo test system

Test animals

Species:

guinea pig

Strain:

other: Albino

Sex:

male

Details on test animals and environmental conditions:

no sufficient data

Study design: in vivo (non-LLNA)

Induction

Induction 1

Route:

intradermal

Vehicle:

physiological saline

Induction 2

Concentration / amount:

induction = 0.1% solution in 0.75% saline
challenge = not specified

Challenge

Challenge 1

Route:

intradermal

Vehicle:

physiological saline

Challenge 2

Concentration / amount:

induction = 0.1% solution in 0.75% saline
challenge = not specified

No. of animals per dose:

20

Details on study design:

Groups of 350 to 450 guinea pigs were given the usual cours of 8 intracutaneous injections of 0.1 % solution in 0.75 % saline made up in deionized water. Challenge doses were given 3 weeks after the last sensitizing dose.

Challenge controls:

no data

Results and discussion

Positive control results:

no data

In vivo (non-LLNA)

Results

Reading:

other: not sensitizing

Group:

test chemical

Dose level:

no data

No. with + reactions:

0

Total no. in group:

20

Clinical observations:

no positive responses were noted in 12 survived animals

Remarks on result:

other: Reading: other: not sensitizing. Group: test group. Dose level: no data. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no positive responses were noted in 12 survived animals.

Any other information on results incl. tables

"It was obvious that these guinea pigs were not a particularly healthy although the survivors seemed to be in fair condition. We concluded that if these compounds are potential sensitizers they are extremely weak. This statement is made because we know that subnormal animals are often refractory to sensitization".

Applicant's summary and conclusion

Interpretation of results:

not sensitising

Remarks:

Migrated information Criteria used for interpretation of results: other: conclusion drawn in the study report

Conclusions:

No positive sensitisation response after challenge exposure to test substance was noted in all survived animals.

Executive summary:

Triethylamine was tested in male albino guinea pigs for its sensitization potential. 0.1% solutions of test material in 0.75% saline was administered to 20 test animals by intracutaneous injection 8 times (not specified if once each day). Challenge doses were given 3 weeks after the last sensitizing dose. 8 animals were infected, killed or died on study. No positive sensitization responses were noted in the 12 survived animals. The animals on study were considered to be not entirely healthy. Therefore if the test substance was a sensitizer, such animals would be more refractory to sensitization. The test substance was considered to be not sensitizing by the author of the study report.