Triethylamine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17. Jun 1958 - 24 Jun 1958

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1960

Report date:

1960

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

observation period was 7 days

Principles of method if other than guideline:

BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
Animals were treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 7 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Test type:

other: acute oral toxicity method (OECD 401)

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triethylamine

EC Number:

204-469-4

EC Name:

Triethylamine

Cas Number:

121-44-8

Molecular formula:

C6H15N

IUPAC Name:

triethylamine

Details on test material:

- Name of test material (as cited in study report): Triaethylamin
- Impurities (identity and concentrations): up to 1 % diaethylamin

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 119 - 200 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 1, 10 and 20 %

Doses:

20, 79, 316, 501, 794, 1260, 5010 cm³/kg bw (15, 58, 230, 366, 580, 920 and 3660 mg/kg bw - conversion in mg/kg is based on the denisty: 0.73 g/cm³).
Two animals also received the TS undiluted at 920 and 3660 mg/kg.

No. of animals per sex per dose:

15 and 58 mg/kg bw: 1 (no gender stated)
230, 366 and 580 mg/kg bw: 5 (no gender stated)
920 and 3660 mg/kg bw: 5 animals were treated with diluted and 1 animal with undiluted test substance.

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

730 mg/kg bw

Remarks on result:

other: no further information available

Mortality:

No animals died in the five lowest dose groups (0/1, 0/1, 0/5, 0/5 and  0/5).  In the 920 mg/kg dose group 4/6 animals died within the first 24  h.  In the 3660 mg/kg dose 1/1 animal died within the first h. The animals that received the undiluted test substance died within approx. 1 h of administration.

Clinical signs:

other: 580 mg/kg bw: 24 h post application unkempt fur was observed. 920 mg/kg bw: strong trembling and convulsions occured and by approx. 2 h 3/6 animals had died; the next day unkempt fur and blood crusted nose and snouts were observed. The animal that receiv

Gross pathology:

The animals that received the undiluted test substance had stomachs filled with dark red contents.

Any other information on results incl. tables

Mortality:

Dose (mg/kg bw)	conc (%)	1 h	24 h	48 h	7 days
3660	100	1/1	1/1	1/1	1/1
3660	20	1/1	1/1	1/1	1/1
929	10	0/5	3/5	3/5	3/5
929	100	1/1	1/1	1/1	1/1
580	10	0/5	0/5	0/5	0/5
366	10	0/5	0/5	0/5	0/5
230	10	0/5	0/5	0/5	0/5
58	1	0/1	0/1	0/1	0/1
15	1	0/1	0/1	0/1	0/1

Applicant's summary and conclusion

Interpretation of results:

moderately toxic

Remarks:

Migrated information medium to moderate Criteria used for interpretation of results: expert judgment

Conclusions:

The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependent manner.

Executive summary:

The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. Triethylamine was administered to rats by gavage as solution in olive oil. Concentrations in vehicle were 1% (15 and 58 mg/kg/bw), 10% (230, 366, 580 and 929 mg/kg/bw), 20% (3660 mg/kg/bw) and undiluted (929 and 3660 mg/kg/bw). No mortalities were observed in the five lowest dose groups. In the 920 mg/kg dose group 4/6 animals died within the first 24  h.  In the 3660 mg/kg dose 1/1 animal died within the first hour. The animals that received the undiluted test substance died within approx. 1 h of administration. The animals that received high doses of the test material showed convulsions and strong trenor. The severity of these effects was enchanced in a dose-dependent manner.