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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from published review
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Criteria for a recommended standard – occupational exposure to furfuryl alcohol.
Author:
US National Institute for Occupational Safety & Health
Year:
1979
Bibliographic source:
DHEW (NIOSH) Publication 79-133
Reference Type:
other: primary citation; Russian article
Title:
The allergenic properties of furanic compounds
Author:
Chernousov AD
Year:
1974
Bibliographic source:
J. Gig. Sanit. 39: 28-32

Materials and methods

Principles of method if other than guideline:
Assessment of skin irritation potential.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Furfuryl alcohol
EC Number:
202-626-1
EC Name:
Furfuryl alcohol
Cas Number:
98-00-0
Molecular formula:
C5H6O2
IUPAC Name:
(furan-2-yl)methanol
Details on test material:
- Name of test material (as cited in study report): Furfuryl alcohol

Test animals

Species:
guinea pig
Strain:
not specified

Test system

Type of coverage:
other: assumed open
Preparation of test site:
not specified
Vehicle:
other: acetone
Controls:
not specified
Amount / concentration applied:
50%, 10% and 1% solutions in acetone
Duration of treatment / exposure:
applied daily for 12 days to a 2.25 cm2 area of skin on the lateral surface of the torso
Number of animals:
No data

Results and discussion

In vivo

Results
Irritation parameter:
other: observation of skin irritation
Time point:
other: not specified
Reversibility:
no data
Remarks on result:
other: 50% in acetone caused some irritating effects including skin dryness, hyperemia, desquamation and necrosis. It is of note that acetone itself was classified under DSD as R66 (repeated exposure causes dryness and cracking).

Applicant's summary and conclusion

Interpretation of results:
other: 50% furfuryl alcohol in acetone caused some skin irritation.
Conclusions:
The author characterised furfuryl alcohol had some irritating effects at 50% only.


Executive summary:

Chernousov (Russian abstract) describes an assessment of skin irritation in guinea pigs in which it was found that topical exposure to 50% furfuryl alcohol in acetone caused some irritating effects including skin dryness, hyperemia, desquamation and necrosis. However this is an unconventional assessment, lacking detail in terms of design and outcome. It is not possible to interpret the observation in the context of skin irritation potential.