Registration Dossier
Registration Dossier
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EC number: 202-626-1 | CAS number: 98-00-0
Neurotoxicity
Administrative data
Description of key information
Furfuryl alcohol is considered to show no significant neurotoxic potential.
Key value for chemical safety assessment
Additional information
In repeated dose studies (16-days and 90-days) no indication for neurotoxic effects was noted. No guideline neurotoxicity studies have been conducted and standard neurotoxicological endpoints (e.g. extended clinical observations, motor activity, functional observations, neuropathology) were not measured in the only published study investigating neurotoxicity (Savolainen and Pfaffli, 1983). At 50 and 100 ppm for 4 to 16 weeks rats were lighter than controls at the end of the experiment (without a clear dose-related response) and high dose rats were reported to have muscle hypotonia from 13th week onwards. Creatine kinase activity in cerebellar homogenate was increased at 50 and 100 ppm, succinate dehydrogenase activity was decreased at 100 ppm. Glial cell fractions showed decreased succinate dehydrogenase (week 16) and creatine kinase activity (weeks 9 and 16) at all dose levels and 2',3'-cyclic nucleotide 3'-phosphohydrolase and acid proteinase activity were increased at 100 ppm in week 16. Basic protein content of isolated myelin fractions was decreased compared to controls at 100 ppm at 16 weeks.
25 ppm was considered to be a NOAEL for nervous system effects.
Differences in the activity levels of specific enzymes in brain homogenates at dose levels also producing lower body weight are considered not to indicate specific neurotoxicity.Justification for classification or non-classification
No evidence of specific neurotoxic effects has been seen at dose levels that do not produce systemic toxicity and no classification is warranted with respect to this endpoint.
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