Registration Dossier
Registration Dossier
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EC number: 202-626-1 | CAS number: 98-00-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The predicted 96 hour algal QSAR EC50 was 170.278 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 170.278 mg/L
- EC10 or NOEC for freshwater algae:
- 25 mg/L
Additional information
The experimental result indicated that the toxicity threshold for furfurylalcohol to algae is 25 mg/L. An EC50 could not be derived from this study.
The USEPA EPIWEB 4.0 QSAR software was used to calculate an algal 96 hour EC50. Within the software the ECOSAR module contains a library of QSARs for predicting aquatic toxicity. ECOSAR Version 1.00 has the potential to identify over 120 chemical classes and calculates QSARs for numerous endpoints and organisms. The QSARs in ECOSAR for both neutral organics and classes are based on a linear mathematical relationship between the predicted log Kow values and the corresponding log of the measured toxicity values (mmol/L) for the training set chemicals within each chemical class of interest. Specific Furfuryl Alcohol phy-chem parameters were used when running ECOSAR and included the measured log Kow for the substance. The results from ECOSAR indicated that furfuryl alcohol’s toxicity was best represented by the benzyl alcohol chemical class. The phys-chem properties of both substances were then analysed to ensure that this was indeed the case. The phys-chem data for Furfuryl Alcohol (FA) show that the substance falls within the domains (limitations) of the ECOSAR software and therefore the calculated QSARs should be Klimisch scored as 2 (reliable with restrictions). It must also be noted that a representative chemical class was found for FA in the software database and this provides additional support for the use of the QSAR. Finally, experimental results for a longer exposure period also indicate that EC10 was 25 mg/L. The predicted 96 hour algal QSAR EC50 was 170.278 mg/L.
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