Registration Dossier
Registration Dossier
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EC number: 200-900-5 | CAS number: 75-77-4
Endpoint summary
Administrative data
Description of key information
There are no studies of sufficient duration that assess the repeated dose toxicity of chlorotrimethylsilane. Therefore results from a key inhalation OECD 422 study on the hydrolysis product, trimethylsilanol have been read-across to support this endpoint for chlorotrimethylsilane. In this study the NOAEC for trimethylsilanol was at least 600 ppm (2666 mg/m3).
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 2 666 mg/m³
Additional information
Chlorotrimethylsilane is hydrolysed very rapidly in the presence of moisture to trimethylsilanol and hydrogen chloride (HCl).Adverse effects following acute exposures at high concentrations can be assumed to be caused by the hydrolysis product HCl. However, this is not the case for repeated exposures at lower concentrations. Potential adverse effects following such exposures could be due to the other hydrolysis product, trimethylsilanol, and it is therefore important to consider these potential adverse effects. However, when considering results of trimethylsilanol, it is important to assume local effects (irritation/corrosion) in addition to the effects observed for trimethylsilanol.
Justification for classification or non-classification
Chlorotrimethylsilane is not classified STOT-RE under Directive 67/548/EEC. Based on read-across results for hydrolysis products, there are no data to suggest that chlorotrimethylsilane should be classified for effects following repeated exposure under Regulation 1272/2008.
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