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Diss Factsheets
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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
“No carcinogenicity studies with phosphoryl trichloride in experimental animals were identified in the available literature. As phosphoryl trichloride hydrolyzes quickly to form hydrochloric and phosphoric acids, chronic effects are expected mostly from exposure to these degradation products” (OECD SIDS for phosphoryl trichloride, 2004).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Phosphoryl trichloride hydrolyzes quickly to form hydrochloric and phosphoric acid. “The resulting anions chloride and phosphate are essential components of every living tissue. They are not expected to produce mutagenic effects” (OECD SIDS for phosphoryl trichloride, 2004). A classification is therefore not justified.
Additional information
“In water, phosphoryl trichloride hydrolyzes to phosphoric acid and hydrochloric acid with t1/2 < 10 seconds (Riess, 2002): POCl3+ 3 H2O→H3PO4+ 3 HCl” (OECD SIDS for phosphoryl trichloride, 2004).
“The hydrolysis product hydrochloric acid gave no indications for an increased tumor incidence after life-time exposure in laboratory animals. Data on phosphoric acid, the second hydrolysis product, are not available, but no specific effects are expected. At low concentrations the hydrolysis products, phosphoric and hydrochloric acid, will be neutralised immediately in the physiologic medium at the portal of entry” (OECD SIDS for phosphoryl trichloride, 2004).
“The resulting anions chloride and phosphate are essential components of every living tissue. They are not expected to produce mutagenic effects. The reduced pH levels could lead to chromosomal changes and DNA damage at the portal-of-entry of phosphoryl trichloride. However, it is unlikely that systemic changes in pH would occur after exposure to phosphoryl trichloride, that are sufficient in magnitude to induce this effect in distant tissues or organs. Nevertheless prolonged irritation could give rise to a constant stimulus to cell proliferation” (OECD SIDS for phosphoryl trichloride, 2004).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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