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Diss Factsheets
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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity, other
- Remarks:
- : in-vitro/in-vivo experiments
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Principles of method if other than guideline:
- Phosphoryl trichloride (and phosphorus trichloride and thiophosphoryl trichloride) are highly toxic based on acute oral and inhalation data with rats. This study considers their mechanisms of toxicity.
- GLP compliance:
- no
Test material
- Reference substance name:
- Phosphoryl trichloride
- EC Number:
- 233-046-7
- EC Name:
- Phosphoryl trichloride
- Cas Number:
- 10025-87-3
- Molecular formula:
- Cl3OP
- IUPAC Name:
- phosphoroyl trichloride
- Test material form:
- liquid
- Details on test material:
- 99% - from Aldrich Chemical (Milwaukee, WI)
Constituent 1
Test animals
- Species:
- other: see exmainations
- Strain:
- other: see examinations
Administration / exposure
- Route of administration:
- other: see examinations
- Vehicle:
- other: see examinations
- Duration of treatment / exposure:
- see examinations
- Frequency of treatment:
- see examinations
- No. of animals per sex per dose:
- see examinations
Results and discussion
Results of examinations
- Details on results:
- Phosphoryl trichloride inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Phosphotrichlorides have high vapor toxicity to houseflies with in vivo inhibition of brain AChE activity correlating with mortality. Phosphoryl trichloride produces cholinergic poisoning signs on ip administration to mice, and give marked in vivo inhibition of serum BChE but not brain AChE activity. Activation of phosphoryl trichloride is confirmed by preparing pure phosphorodichloric acid and its potassium and dicyclohexylamine salts that reproduce the action of phosphoryl trichloride as in vitro AChE inhibitors and toxicants in mice.
Effect levels
- Dose descriptor:
- other: The mechanisms of toxicity were examined.
- Remarks on result:
- other: see 'Remarks'
- Remarks:
- Phosphoryl trichloride is highly toxic based on acute oral and inhalation data with rats. The mechanisms of toxicity were examined. Phosphoryl trichloride inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Phosphotrichlorides have high vapor toxicity to houseflies with in vivo inhibition of brain AChE activity correlating with mortality. Phosphoryl trichloride produces cholinergic poisoning signs on ip administration to mice, and give marked in vivo inhibition of serum BChE but not brain AChE activity. Activation of phosphoryl trichloride is confirmed by preparing pure phosphorodichloric acid and its potassium and dicyclohexylamine salts that reproduce the action of phosphoryl trichloride as in vitro AChE inhibitors and toxicants in mice.
Applicant's summary and conclusion
- Executive summary:
Phosphoryl trichloride is highly toxic based on acute oral and inhalation data with rats. The mechanisms of toxicity were examined.
Phosphoryl trichloride inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Phosphotrichlorides have high vapor toxicity to houseflies with in vivo inhibition of brain AChE activity correlating with mortality. Phosphoryl trichloride produces cholinergic poisoning signs on ip administration to mice, and give marked in vivo inhibition of serum BChE but not brain AChE activity. Activation of phosphoryl trichloride is confirmed by preparing pure phosphorodichloric acid and its potassium and dicyclohexylamine salts that reproduce the action of phosphoryl trichloride as in vitro AChE inhibitors and toxicants in mice.
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