Bis(2-dimethylaminoethyl)(methyl)amine

Endpoint summary

Additional information

Short-term ecotoxicological data on the effects of Pentamethyldiethylentriamine (PMDETA) are available for freshwater fish, invertebrates, algae and microorganisms (see the table below). Based on data from acute aquatic toxicity tests the PMDETAhas been classified with aquatic chronic 3.

Major taxon	Test species	LC50 / EC50/ NOEC	Remarks	Reference
Fish	Oncorhynchus mykiss	LC50 (96 h): 157 mg/L test mat. (meas.)	key study	Mayes et al., 1989
	Leuciscus idus	LC50 (96 h): ca. 220 mg/L test mat. (nominal)		BASF AG, 1987
Invertebrates	Daphnia magna	EC50 (48 h): 54.9 mg/L test mat. (nominal)	key study	Roupcova M., 2012a Kalhousova M., 2012
	Daphnia magna	EC50 (48 h): 76 mg/L test mat. (meas.)		Mayes et al., 1989
Algae	Desmodesmus subspicatus	ErC50 (72 h): 78.3 mg/L test mat. (nominal) ErC10 (72 h): 40.2 mg/L test mat. (nominal)	key study	Roupcova M., 2012b Roupcova M., 2012c Kalhousova M., 2012
Microorganisms	activated sludge, domestic	NOEC (30 min): 1000 mg/L act. ingr. (nominal)	key study	BASF AG, 1991c
	activated sludge, industrial	NOEC (30 min): 660 mg/L test mat. (nominal)		BASF AG, 1987

 

Regarding the long term toxicity test for aquatic compartment in accordance with column 2 of REACH Annex IX, the studies shall be proposed if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The substance is not poorly water soluble. As the exposure assessment (see chapter 9) does not indicate the need to investigate further the effects on aquatic organisms (as all the RCRs to all the compartments are well below 1 and all the supported uses are therefore assessed to be safe) no further long-term testing is proposed for aquatic compartments.