L-(+)-lactic acid

Toxicity to terrestrial arthropods

Link to relevant study record(s)

Reference

Endpoint:

toxicity to bees: acute contact

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: Pesticide Assessment Guidelines. FIFRA Subdivision L, Hazard Evaluation: Insecticide and Rodenticide Act, Non-Target Insects.Environmental Protection Agency, Office of Pesticide Programs. October,1982.

GLP compliance:

no

Application method:

contact

Analytical monitoring:

not specified

Vehicle:

yes

Details on preparation and application of test substrate:

Vehicle: water

Test organisms (species):

Apis mellifera

Animal group:

Hymenoptera (honeybees)

Details on test organisms:

TEST ORGANISM
- Common name: Honeybee
- Source: Own breed of the test facility
- Age at test initiation (mean and range, SD): < 3 weeks
- Weight at test initiation (mean and range, SD): No data
- Date of collection: No data
- Cultural background (if honeybees): No data
- Disease free: No data
- Kept according to standard practices: Yesm according to "Bee Keeping in Maryland," Cooperative Extension Services, University of Maryland, Bulletin 223, 1977.

ACCLIMATION
- Acclimation period: No data
- Acclimation conditions (same as test or not): No data
- Feeding: No data
- Health during acclimation (any mortality observed): No data

Study type:

laboratory study

Limit test:

no

Remarks:

Single dosing

Post exposure observation period:

48 hours

Test temperature:

No data

pH (if soil or dung study):

Not applicable

Humidity:

No data

Photoperiod and lighting:

No data

Nominal and measured concentrations:

6.9, 12.8, 25.1, 50.2, and 100.4 µg/bee (nominal)

Key result

Duration:

48 h

Dose descriptor:

LD50

Effect conc.:

> 100.4 µg per animal

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

yes

Conclusions:

The contact LD50 value of SY-83 (L(+)-lactic acid) in the honey bee was determined to be greater than 100.4 µg/bee, the highest concentration tested.

Executive summary:

Mortality rates in all five treatment groups were similar to those observed in the control and solvent control groups. Mortalities did not appear to be treatment related. In conclusion, SY-83 was classified as relatively non-toxic to honey bees. The 48 hour contact LD50 value for SY-83 to honey bees was greater than 100.4 µg/bee, the highest dosage tested.

Description of key information

The contact LD50 value of L-(+)-lactic acid in the honey bee was determined to be greater than 100.4 µg/bee, the highest concentration tested.