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EC number: 278-770-4
CAS number: 77804-81-0
material was subject to a test of eye irritancy according to FDA
guidelines (Fed. Reg. Vol. 38, No. 187, p. 27019, 1973). 100 mg of
in polyethylenglycol were applied to one eye of six animals each. The
eyes were washed 24 h after application and eye responses were noted for
72 h after start of the exposure. Only slight effects could be observed,
conjunctiva redness score of 1 in 5/6 animals at the 24 h reading and in
2/6 animals at the 48 h reading. This effect was fully reversible within
72 h. Only slight other effects (iridial effects, score = 1 in 3/6
animals at the 1 h reading; Cornea score = 1 in 1/6 animals at 1 h
reading; Chemosis score = 1 in 6/6 animals at the 1 h reading and in 3/6
animals at the 7 h reading) were observed after 1 and 7 h, these effects
were reversible within 24 h.
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