Registration Dossier
Registration Dossier
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EC number: 201-116-6 | CAS number: 78-42-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Studies on Tri-(2-Ethylhexyl)-Phosphate
- Author:
- MacFarland H.N.; Punte C.L.
- Year:
- 1 966
- Bibliographic source:
- Archives of Environmental Health Vol. 13, pp.13-20
Materials and methods
- Principles of method if other than guideline:
- other: Acute toxicity i.v. in rabbits
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Details on test material:
- Mol wt: 434.6;
Sp g: 0.925 at 20 C;
n25D: 1.4473;
Surface tension: 31 dynes/sq cm;
Viscosity: 10.2 cp;
Vap press: 2 mm Hg at 200 C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 6.9, 15,4, 36,9, 75.9 and 358.0 mg/kg bw.
- No. of animals per sex per dose:
- 6/ dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 358 mg/kg bw
Any other information on results incl. tables
No deaths occured in the first four groups; two of the six rabbits received the highest dose died within 24 hours of injection.
Applicant's summary and conclusion
- Executive summary:
In an acute intravenous toxicity study in New Zealand White rabbits, the animals in groups of six each were given single i.v. injections of the test substance. The following doses were injected: 6.9, 15.4, 36.9, 75.9 and 358.0 mg/kg bw. No deaths occurred in the first four groups; two of the six rabbits received the highest dose died within 24 hours of injection. Therefore the LD50 for i.v. injection was >358.0 mg/kg bw.
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