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EC number: 202-597-5
CAS number: 97-63-2
There are data for EMA for oral and inhalation routes. There are no reliable data for EMA for the dermal route although there are data for other members of the lower alkyl methacrylate esters category that are consistent and sufficient to enable an assessment for this endpoint. Available data indicate a very low acute toxicity of EMA.
The LD50 estimated by the method of Bliss clearly demonstrates that the test material is of low acute toxicity by the oral route.
A reliable published acute oral LD50 in rats was 13424 mg/kg bw.
In a valid guideline study acute (4 hr) inhalation LC50 in rats was 55
In the key
study (Deichmann, 1941) the LD50 for EMA was determined to be 13424
was performed before GLP and OECD guidelines were established and
therefore only basic data were available. However, it is broadly
consistent with data obtained in other species and with other esters in
the category of lower alkyl methacrylate esters and,
therefore, the entire data base provided sufficient information to
assess the acute oral toxicity.
toxic potential of ethyl methacrylate after inhalation exposure in rats
is low (LC50 = 55 mg/L 4 h exposure (Kelly, 1993)
data exist for EMA by the dermal route. Valid data for shorter (MMA) and
longer (n-BMA) esters within the category, as well as two early
pre-guideline studies (invalid according to Klimisch criteria) on the
longest ester (2-EHMA), that are sufficient for the assessment and that
indicate low acute dermal toxicity.
studies for toxicity using other routes of exposure (i.p.,) using
different species which are not considered being relevant for the
EMA is of low acute toxicity by the oral and inhalation routes. By
analogy to shorter and longer esters of the lower alkyl methacrylate
ester category EMA is considered to be of low dermal toxicity. Based
on the available information ethyl
methacrylate is not required to be classified for its acute toxicity
potential according to 67/548/EEC and UN-GHS requirements, respectively.
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