Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-597-5
CAS number: 97-63-2
Reevaluated according CLP criteria
Comparison with CLP criteria:
Remark: Exposure time was higher than 4 hours, observation time
only 72 hours.
Two scores were > 2.3 but observation time too short. The highest
mean erythema score is 2 for 3/6 animals. The highest edema score is 3
for 1/6 animals. The observation time was too short to demonstrate
Shaved and scarifized skin (not used for evaluation):
acc. DSD criteria
2 h Exposure, shaved skin, occlusive
primary dermal irritation study according to “Federal Hazardous
Substances Labelling Act Regulations, Section 191.11, Federal Register:
29, 13009 (1964), 6 young adult New Zealand White rabbits were dermally
exposed to 0.5 mL of EMA for 24 hours to 2.5x 2.5 cm body surface area
of the shaved/scarified skin. Animals then were observed for 3 days.
Irritation was scored by the Draize method. This scoring system is
similar to OECD guideline 404.
animals with the shaved intact skin were evaluated for C&L purposes.
24 h after
application 2 animals showed very slight (score1) and 4 animals well
defined (score 2) signs of erythema and 3 animals very slight (score 1),
2 animals slight (score 2) and 1 animal moderate (score 3) edema. 72 h
after application 2 animals showed no erythema (score 0), 2 animals very
slight (score 1) and 2 animals well defined erythema (score 2). No edema
were observed after 72 h in 2 animals, slight edema (score 2) in 2
animals and moderate (score 3) in 2 animals. Acc. CLP criteria in 2/6
animals mean edema scores (24 +72h) were > 2.3. As observation time was
only 72 h and reversibility could not be observed EMA is considerd as
irriating to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again