Registration Dossier

Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more species of wild and domestic birds; M143
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Arch. Environ. Contam. Toxicol. 1983, 12, 355-382; Schafer, E. W. et al

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
The chemicals included technical and analytical grade, pesticidal, pharmaceutical, and other commercial or experimental compounds that were either purchased or solicited from cooperating firms. Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol, according to methods described by DeCino et al. (1966), Schafer (1972), and Schafer et al. (1967). Other oral dosing methods were occasionally used (pellets, gelatin capsules). LDs0 values were calculated by the method of Thompson (1948), Thompson and Weil (1952), and Well (1952).
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Dose method:
other: oral

Test organisms

Test organisms (species):
other: redwing blackbird, starling

Study design

Limit test:
yes
Total exposure duration (if not bolus):
2 wk

Results and discussion

Effect levels
Duration (if not bolus):
6 wk
Dose descriptor:
LD50
Effect level:
> 100 mg/kg bw
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Other details not available

Applicant's summary and conclusion

Executive summary:

The LD50 value of the substance in Redwing blackbird, starling is found to be >100mg/kg by oral route.