Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
M143
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Lenga, R. E. (Ed.) Sigma-Aldrich Library of Chemical Safety Data 2nd ed., 1988, 2, 2259, Sigma-Aldrich, Milwaukee, WI, USA.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
DOSE database
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
animal: species unspecified
Reversibility:
no data
Remarks on result:
other: Irritating to the skin
Irritant / corrosive response data:
Irritating to the skin (species unspecified)

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

The substance is found to be irritating to the skin (species unspecified)