Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
M143
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Lenga, R. E. (Ed.) Sigma-Aldrich Library of Chemical Safety Data 2nd ed., 1988, 2, 2259, Sigma-Aldrich, Milwaukee, WI, USA.

Materials and methods

Objective of study:
absorption
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
DOSE database
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
not specified

Test animals

Species:
human
Sex:
not specified

Administration / exposure

Route of administration:
dermal
Vehicle:
unchanged (no vehicle)

Results and discussion

Preliminary studies:
Absorption into the body leads to the formation of methaemoglobin, which in sufficient amounts causes cyanosis.

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Absorption into the body leads to the formation of methaemoglobin, which in sufficient amounts causes cyanosis.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Executive summary:

Absorption into the body leads to the formation ofmethaemoglobin, which in sufficient amounts causes cyanosis