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EC number: 292-562-0
CAS number: 90640-43-0
The 96h-LC50 to Danio rerio (zebra fish) is 0.148 mg/L in an OECD TG 203 test under GLP.
Seven acute toxicity tests with fish are available for various
alkyl-1,3-diamines with C12-18 chains (all reliability 2) which can be
used for read across to this substance N-C12 -14 -alkyltrimethylenediamines
(CAS No. 90640 -43 -0). The tests reveal a comparable toxicity for the
diamines with alkyl chain lengths ranging from C12 to C18,
independent of the alkyl chain lenght. Justification for the read-across
is provided in the attached document.
The tests were considered to be valid with restrictions for various
reasons. The test concentrations were not analytically verified because
a reliable specific method of analysis was not available at the time
when the test was performed. Further concerns related to the poor
solubility of the test substances and partial sorption onto the walls of
The available acute fish toxicity data are all determined with the same
species, endpoint, test duration, life stage and testing conditions and
they have te same reliability rating. As the results are not more than
order of magnitude apart (96h LC50 range 0.08 - 0.35 mg/L),
The geometric mean of all 7 tests has been calculated resulting in LC50
of 0.150 mg/L. It can be concluded that fish are less sensitive to the
alkyl-1,3 -diamines than daphnia and algae in acute toxicity tests based
on the geometric mean of all available acute test data. Therefore it
can be concluded as well that fish toxicity is not a critical endpoint
for the PNEC derivation, Classification and PBT assessment. The
experimental value of 0.148 mg/L is selected as key value for the CSR.
Acute toxicity to fish
0.1<96h-LC50 < 0.35 mg/L
Reliability 2, GLP
96h-LC50 = 0.148 mg/L
96h-LC50 = 0.32 mg/L
96h-LC50 = 0.16 mg/L
96h-LC50 = 0.1 mg/L
Akzo Nobel 1990
96h-LC50 = 0.08 mg/L
Akzo Nobel 1993
96h-LC50 = 0.15 mg/L
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