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EC number: 217-983-9
CAS number: 2031-67-6
Oral (OECD TG 401), rat: LD50 > 2007 mg/kg bw (limit test)
Dermal: (OCED TG 402), rat: LD50 > 2007 mg/kg bw (limit test)
Inhalation (OCED TG 403), rat, 4 h exposure: LC50 > 13500 mg/m³ (limit
It was not stated whether the tested concentration was the highest
achievable concentration, but taken into account the molecular weight
(178.3 g/mol) and the vapour pressure of the test substance (100 Pa at
25 °C and 1013 hPa) a saturated vapour concentration of 7190 mg/m³ (7.19
mg/L) can be calculated. It is therefore assumed that the tested
concentration was the highest achievable dose in the test atmosphere and
a higher exposure concentration is unlikely.
Table 1: Number of
Concentration and mortality per animals treated
Analytical Conc. (mg/L)
Table1. Number of
animals dead and with evident toxicity
Number with evident toxicity (/total)
were chosen as key when the available study was of relevance and
sufficient quality for classification, labelling and risk
assessment. Other available data are included as supporting studies.
key acute oral toxicity study which was conducted in compliance with GLP
and according to the now deleted OECD TG 401, reports an LD50
value of >2007 mg/kg bw for triethoxy(methyl)silane. There were no
mortality or marked systemic effect in rats at the limit dose of 2007
mg/kg bw (Hazleton France, 1992a). A supporting acute oral toxicity
study conducted without compliance to GLP and similar to OECD TG 401 was
also available on triethoxy(methyl)silane, which reported oral LD50
values of 7627 and 10057 mg/kg bw (dose given in mL/kg, converted using
a relative density of 0.89), for males and females, respectively (Bushy
Run Research Centre, 1981).
A second supporting acute oral toxicity study conducted with
triethoxy(methyl)silane according to OECD TG 423 in compliance with GLP
reported a LD50
2000 mg/kg bw for female rats (METI, 2011). The results of all
three experiments are
in agreement with the low acute oral toxicity potential of
key acute inhalation toxicity study which was conducted in compliance
with GLP and according to OECD TG 403 reports an LC50 of >13500 mg/m³
for triethoxy(methyl)silane vapour in rats after 4 hours. One animal
from a total of ten died. The study reported that it was technically not
possible to determine the particle size, presumably because the
substance was emitted mainly as vapour. It
was not stated whether the tested concentration was the highest
achievable concentration, but taking into
account that the measured concentration (13.5 mg/L) greatly exceeds the
saturated vapour concentration (Hoechst,
AG 1991). A limited report of an acute
inhalation toxicity study without guideline compliance or GLP was also
available, which reports one death in ten rats following a 6-hour
exposure to the 'substantially saturated vapour’ of
Run Research Center, 1981). The
exposed concentration was not given; however, this study further
supports the lack of acute toxicity by the inhalation route of
key acute dermal toxicity study which was conducted in compliance with
GLP and according to OCED TG 402, reports an LD50 value of
>2007 mg/kg bw for triethoxy(methyl)silane. There were no mortality or
marked systemic effect in rats at the limit dose of 2007 mg/kg bw (24
hour exposure) (Hazelton France, 1992b). A supporting acute dermal
toxicity study which was not compliant with GLP but conducted in
accordance with generally accepted scientific standards was also
available, which reports an LD50 value of 11837 mg/kg (males)
and >14240 mg/kg (females) (dose given in ml/kg, converted using a
relative density of 0.89) (Bushy Run Research Center, 1981)
thereby, further supporting the lack of acute toxicity potential by the
dermal route of triethoxy(methyl)silane.
available data on acute toxicity of the registered substance do not meet
the criteria for classification according to Regulation 1272/2008 and
are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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