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EC number: 217-983-9
CAS number: 2031-67-6
(96-hour) LC50: >500 mg/l mortality Danio rerio, reliability 1.(96-hour) LC50: 10000 mg/l mortality, hydrolysis product (using an appropriate calculation method), reliability 2.
A 96-hour LC50 value of >500 mg/l and NOEC of ≥500 mg/l have been
determined for the effects of the test substance on mortality of Danio
rerio (tested as Brachydanio rerio) based on nominal concentration of
the substance. The study was conducted according to a standard guideline
(EU Method C.1, Acute Toxicity for Fish) and to GLP and so was selected
as key study (1994).
LC50 values in the range of 400 to >1000 mg/l are available from
secondary literature (three studies) of lower reliability. However, as
the substance rapidly hydrolyses (half-life of approximately 5.5 hours)
to methylsilanetriol, it is very likely that the test organisms were
primarily exposed to the hydrolysis product retained in the test media.
A 96 hour LC50 of 10000 mg/l for fresh water fish was derived for the
hydrolysis product using an appropriate calculation method (QSAR adapted
from ECOSAR v1.00) for silicon substances (2011).
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