Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-911-8 | CAS number: 89-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biotransformation and kinetics
Administrative data
- Endpoint:
- biotransformation and kinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental results from study conducted according to acceptable principles and reported in peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- The ability of Armillariella mellea to transform cyclic monoterpenic alcohols and their acetates
- Author:
- Draczynska-Lusiak B, Siewinski A
- Year:
- 1 991
- Bibliographic source:
- J Basic Microbiol 31(5), 363-369
Materials and methods
- Principles of method if other than guideline:
- A biotransformation with Armillariella mellea was conducted. An amount of 0.8 to 2 g of the substance was added to well growing fungal cultures. The standard study lasted for 10 to 12 days. After the transformation phase, the mycelium was separated from nutrient solution. The solution was salted out with ammonium sulphated and extracted with ethyl ether. The extract was analysed by gas chromatography and yields of individual products were calculated.
- GLP compliance:
- no
- Type of medium:
- terrestrial
Test material
- Reference substance name:
- Menthyl acetate
- EC Number:
- 201-911-8
- EC Name:
- Menthyl acetate
- Cas Number:
- 89-48-5
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 5-methyl-2-(propan-2-yl)cyclohexyl acetate
Constituent 1
Results and discussion
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 8-hydroxymenthyl acetate
- Identifier:
- other: name as given in publication
- Identity:
- 8-hydroxymenthyl acetate
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 3,8-p-menthan-diol
- Identifier:
- other: name as given in publication
- Identity:
- 3,8-p-menthan-diol
- No.:
- #3
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 2-isopropyl-5-methylcyclohexanol
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 201-939-0]
- CAS number:
- 89-78-1
- Identity:
- Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1?,2ß,5?)-
- Identity:
- Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-
- Identifier:
- CAS number
- Identity:
- 15356-70-4
- Identifier:
- other: EINECS name
- Identity:
- Menthol
- Molecular formula:
- C10H20O
- Molecular weight:
- 156.265
- SMILES notation:
- OC(C(CCC1C)C(C)C)C1
- InChl:
- InChI=1/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3
Any other information on results incl. tables
Racemic menthyl acetate underwent biotransformation: the main compounds were 8-hydroxymenthyl acetate and 3,8-p-menthandiol. These were formed as the main components in proportions 28 and 24% with respect to the total of isolated products. No menthyl acetate was isolated at the end of the transformation study.
A second experiment was conducted, in which two subsequent transformation studies were conducted with the very same fungal culture. A. mellea transformed menthyl acetate by simultaneous (not subsequent, as before) hydrolysis of ester bond and hydroxylation of unreacted ester in this second study and the resulting main compounds were menthol and 3,8-p-menthandiol.
Applicant's summary and conclusion
- Conclusions:
- In a study with fungal cultures of A. mellea the substance menthyl acetate was biotransformed to a significant extent.
- Executive summary:
A biotransformation with Armillariella mellea was conducted. An amount of 0.8 to 2 g of the substance was added to well growing fungal cultures. The standard study lasted for 10 to 12 days. After the transformation phase, the mycelium was separated from nutrient solution. The solution was salted out with ammonium sulphated and extracted with ethyl ether. The extract was analysed by gas chromatography and yields of individual products were calculated. Racemic menthyl acetate underwent biotransformation: the main compounds were 8-hydroxymenthyl acetate and 3,8-p-menthandiol. These were formed as the main components in proportions 28 and 24% with respect to the total of isolated products. No menthyl acetate was isolated at the end of the transformation study.
A second experiment was conducted, in which two subsequent transformation studies were conducted with the very same fungal culture. A. mellea transformed menthyl acetate by simultaneous (not subsequent, as before) hydrolysis of ester bond and hydroxylation of unreacted ester in this second study and the resulting main compounds were menthol and 3,8-p-menthandiol. No explanation for the different outcome of the two studies was provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.