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EC number: 202-924-1
CAS number: 101-20-2
Response of human subjects tested with the
test chemical in aqueous soap suspension (Draize procedure)
Draize test was performed to evaluate the
dermal sensitization potential of the test chemical.
200 normal human volunteers aged between 21
-50 years were used for the study. 0.5 g of 1.5% test chemical was
applied to the upper lateral portion of the arm, covered with an
occlusive patch, and removed after 48 or 72 hours.10 epicutaneous
applications were administered successively to the same site for
induction. After a rest period of 2 weeks, the challenge patch was
applied for 72 hours, the reactions were read. Skin reactions were
assigned four grades of intensity: 1 = erythema; 2
= erythema snd induration; 3
=vesiculation;and 4 =bulla formation.
The test chemical was not a contact
sensitizer when 1.5% test chemical in aqueous soap suspension was used
for induction. Hence, the test chemical was considered for not
sensitizing to skin
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