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EC number: 202-924-1
CAS number: 101-20-2
Long term toxicity of test chemical
were studied and determine on the reproduction of daphnia magna. The
LOEC was observed to be 0.0047 mg/L for 21 days based on the effect on
Based on the various long term studies
available for the test chemical, studies were reviewed to determine the
toxic nature of test chemical on the mobility and reproduction of
aquatic invertebrates. The studies are as mentioned below:
In the first long term toxicity of
test chemical were studied and determine on the reproduction of daphnia
magna. The LOEC was observed to be 0.0047 mg/L for 21 days based on the
effect on reproduction.
Above study was supported by the below
study from peer reviewed journal. 8 days long term toxicity studies were
conducted to test the effect of chemical on ceriodaphnia .Five
concentrations and blanks were prepared with dechlorinated tap water for
each antimicrobial test, and the survival and the number of neonates was
counted for eight days, when most of the Ceriodaphnia had finished
delivering three broods. The solutions were replaced every 48 h (i.e. a
semi-static system) and the concentration before and after the
replacement was analyzed using the HPLC. Only the numbers of first three
broods were counted and compared with the blanks. Multiple comparisons
were conducted to determine NOEC values as presented above for the algal
test. After the exposure period of 8 days of chemical with Ceriodaphnia,
no effect were observed on the survival rate and reproduction rate of
Ceriodaphnia at the concentration 0.0019 mg/l. Thus based on the NOEC
value chemical consider to be toxic and classified as aquatic chronic 1
as per the CLP classification criteria.
Similar long term toxicity of test
chemical were studied on Americamysis bahia. Test conducted under the
flow- through system for 28 days. The effective concentration (EC50)
value of test chemical in Americamysis bahia(Opossum Shrimp) in a 28
days study based on growth was observed to be > 0.001 mg/L. Thus
considering the value from CLP Criteria for aquatic classification of
the substance, it is concluded that test chemical could exhibit short
term toxicity to aquatic invertebrate (Americamysis bahia) and
classified in Aquatic chronic category 1.
Aim of this study was to determine the
effect of test chemical on the aquatic invertebrates. Test conducted
under the flow-through system in which effect of chemical were tested by
observing the effect of chemical on mortality and survival rate of
daphnia magna. The Low observed effect concentration (LOEC) of test
chemical on Daphnia magna in 21 days study on the basis of effect on
mortality was determine to be 0.05 mg/L.
In the fifth study from secondary
source, 21 days long term toxicity studies were conducted to test the
effect of test chemical on daphnia magna. The NOEC was observed to be
0.0029 mg/L for 21 days based on the effect on reproduction.
Thus based on the overall studies from
peer reviewed journal, authoritative database and secondary sources,
chemical consider to be toxic and classified as aquatic chronic 1 as per
the CLP classification criteria.
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