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EC number: 202-924-1
CAS number: 101-20-2
a reproductive toxicity study, the effect of the test chemical was
evaluated in male Sprague-Dawley rats for 10 days. The seven-week-old
male Sprague-Dawley rats received either a normal diet or a diet
supplemented with the test chemical (0.25% in diet). No mortalities were
observed in the males. All organs were weighed at time of sacrifice
before being subjected to microscopic examination or analysis for
protein and DNA contents. Terminal mean body weight was 5.1% higher in
the treated group compared to the control group. Food intake was not
measured. Absolute liver weight was significantly increased in the 2500
ppm treatment group compared to the control group. No statistically
significant differences in absolute organ weights were observed for the
kidneys, adrenal glands or testes. Accessory sex organs were
significantly enlarged in the 2500 ppm treatment group, with seminal
vesicles weighing 42% more, ventral prostate 37% more, LABC 136% more,
and glans penis 35% more. Protein and DNA contents in ventral prostrate,
LABC muscle and glans penis were significantly elevated in the 2500 ppm
treatment group. There were no gross abnormalities of any of the
accessory sex glands, testes or penis among the treated animals.
Histologically, all tissues appeared normal and there were no consistent
histological differences between the two groups.
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