1H-Imidazolium, 3-ethyl-1-methyl-, methanesulfonate (1:1)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: OECD guideline study conducted according to GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-ethyl-3-methyl-1H-imidazol-3-ium methanesulfonate

EC Number:

604-453-0

Cas Number:

145022-45-3

Molecular formula:

C6 H11 N2. C H3 O3 S

IUPAC Name:

1-ethyl-3-methyl-1H-imidazol-3-ium methanesulfonate

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

6 (2 x 3 animals)

Control animals:

no

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occurred.

Clinical signs:

other: In one animal of the first administration group dyspnoea and piloerection were observed from hour 0 until hour 5. Impaired general state was seen in this animal at hour 0 and from hour 4 to hour 5, interrupted by poor general state, which was noted from h

Gross pathology:

There were no macroscopic pathological findings in the animals sacrificed at the end of
the observation period.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information

Conclusions:

Under the conditions of this study the median lethal dose of EMIM Methansulfonat after oral administration was found to be greater than 2000 mg/kg bw in rats.

Executive summary:

In an acute oral toxicity study performed according to the Acute Toxic Class method, 2000 mg/kg bw of the undiluted test item EMIM Methansulfonat was administered to two test groups of three fasted Wistar rats by gavage. The mean body weight increased within the normal range throughout the study period. There were no macroscopic pathological findings in the animals sacrificed at the end of the observation period. The acute oral LD50 was calculated to be greater than 2000 mg/kg bw.